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G-protein-coupled receptors (GPCRs) influence many steps in tumorigenesis, including proliferation, survival, angiogenesis, metastasis and evasion of the immune system. This Review provides an overview of the various roles of GPCRs in cancer and their potential as therapeutic targets.
Monoclonal antibodies (mAbs) that regulate the immune response are now being clinically evaluated as anticancer agents. This Review discusses their progress to date and the possibilities for combining these antibodies with other cancer treatments.
A new generation of promising anti-mitotic therapies that target proteins with specific functions in mitosis has been developed. As these drugs enter phase I and II trials, what do we know about their mechanism of action and their therapeutic range, and which patients will benefit?
The term myelodysplastic syndromes covers various diseases that are caused by ineffective haematopoiesis in one or more lineages of the bone marrow. How do these diseases arise, and what are the best methods for treating these patients?
The launch of phase '0' trials has generated much discussion in the cancer research community. This Perspective, written by scientists at the US National Cancer Institute, discusses the aims of these trials, gives some practical advice for conducting them and addresses several outstanding questions.
The microenvironment has a crucial role in cancer development, which suggests that microenvironmental targets should be investigated for chemoprevention. What are some of the potential targets and how might they be modulated?
In Cappadocia, Turkey, a mesothelioma epidemic causes 50% of all deaths in three small villages. This manuscript reports, from a personal viewpoint, the scientific advances that have come from studying the families who have an inherited predisposition to develop this disease and the social problems that they face.
