Progress
Nature Reviews Cancer 7, 819-822 (November 2007) | doi:10.1038/nrc2232
microRNAs join the p53 network — another piece in the tumour-suppression puzzle
Lin He1, Xingyue He1,2, Scott W. Lowe1 & Gregory J. Hannon1 About the authors
Abstract
Several recent studies have found a conserved microRNA (miRNA) family, the miR-34s, to be direct transcriptional targets of p53. miR-34 activation can recapitulate elements of p53 activity, including induction of cell-cycle arrest and promotion of apoptosis, and loss of miR-34 can impair p53-mediated cell death. These data reinforce the growing awareness that non-coding RNAs are key players in tumour development by placing miRNAs in a central role in a well-known tumour-suppressor network.
Author affiliations
- Lin He, Xingyue He, Scott W. Lowe and Gregory J. Hannon are at the Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.
- Xingyue He is at the Program in Genetics, Stony Brook University, Stony Brook, New York 11794, USA.
Correspondence to: Gregory J. Hannon1 Email: hannon@cshl.edu
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