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Glioblastoma stem cells might be dependent on cues from aberrant vascular niches that mimic the normal neural stem cell niche. What are the implications of these findings for treatment of this disease?
Studying metastasis has been difficult because until recently only the end result (metastases) could be observed. Advances in imaging technology have enabled us to begin to unravel the steps of metastasisin vivo.
Mantle cell lymphoma, characterized by proliferation of mature B lymphocytes, is one of the most aggressive lymphomas. What molecular pathways are involved in its pathogenesis, and how can these be exploited to predict patient prognosis and design new therapies?
Fatty acid synthase (FASN) catalyses the synthesis of fatty acids, and this synthetic pathway is upregulated in many tumours. How might FASN and increased lipogenesis be involved in cancer, and is FASN a valid therapeutic target?
Approximately 25% of lung cancer cases worldwide are not attributable to smoking, accounting for over 300,000 deaths each year. What do we know about this unique but poorly characterized disease?
Proteases have long been associated with cancer progression and metastasis, however studies have also revealed proteases with tumour-suppressive effects. What are the implications of these findings?
