Table of contents
January 2007 Vol 7 No 1
From the editors
p1 | doi:10.1038/nrc2060
Research Highlights
Tumorigenesis: When DNA damage prevents cancer
p3 | doi:10.1038/nrc2056
Oncogenic signalling: Mysteries of addiction
p4 | doi:10.1038/nrc2058
Cancer stem cells: BMPs on the brain
p4 | doi:10.1038/nrc2065
Therapy: Inhibiting the inhibitors
p5 | doi:10.1038/nrc2052
Tumorigenesis: Licensed to cause chaos
p6 | doi:10.1038/nrc2053
Prognosis: Prognostic proteasome
p6 | doi:10.1038/nrc2057
In brief
In Brief
p6 | doi:10.1038/nrc2062
Tumour microenvironment: Remodelling resistance
p7 | doi:10.1038/nrc2055
Metastasis: Go forth and multiply
p8 | doi:10.1038/nrc2059
In the news
News to phone home about
p8 | doi:10.1038/nrc2061
Metastasis: Minimizing the movement
p8 | doi:10.1038/nrc2063
In brief
In Brief
p9 | doi:10.1038/nrc2064
Reviews
The natural history of cervical HPV infection: unresolved issues
Ciaran B. J. Woodman, Stuart I. Collins and Lawrence S. Young
p11 | doi:10.1038/nrc2050
The identification of high-risk human papillomavirus types as a necessary cause of cervical cancer offers the possibility of improving cervical cancer detection and prevention. What uncertainties need to be clarified for these possibilities to be realized?
Computational prediction of cancer-gene function
Pingzhao Hu, Gary Bader, Dennis A. Wigle and Andrew Emili
p23 | doi:10.1038/nrc2036
A significant problem in cancer biology is determining the functions of uncharacterized cancer-associated genes discovered from genomic and proteomic datasets. This Review explores how cancer-gene function can be deduced using computational and statsitical methods.
Cancer phenomics: RET and PTEN as illustrative models
Kevin M. Zbuk and Charis Eng
p35 | doi:10.1038/nrc2037
Phenomics is the systematic and meticulous collection, objective documentation and cataloguing of phenotypic data at many levels. This Review describes the possible uses of phenomics in cancer research, using the examples of RET and PTEN phenomics.
Perspectives
Opinion
Chemoprevention of breast cancer with selective oestrogen-receptor modulators
V. Craig Jordan
p46 | doi:10.1038/nrc2048
Recent data highlight the usefulness of the selective oestrogen-receptor modulators (SERMs) tamoxifen and raloxifene for the prevention of breast cancer. What have we learned about oestrogen modulation, and how can this inform the use of SERMs for both cancer therapy and prevention?
Innovation
The Connectivity Map: a new tool for biomedical research
Justin Lamb
p54 | doi:10.1038/nrc2044
The Connectivity Map database aims to connect diseases with the genes that cause them and drugs that could treat them. How does this new resource work, and how can it be used by the cancer research community?
Science and society
Understanding global nutrition dynamics as a step towards controlling cancer incidence
Barry M. Popkin
p61 | doi:10.1038/nrc2029
Many cancers have been linked to nutrition and obesity. Although these problems have traditionally affected affluent people and countries, they are rapidly becoming problems of poverty. Understanding the factors behind these shifts may help us to reduce obesity and cancer risk.
Correspondence
Correspondence: Inclusion of the ASH1 gene that governs the neuroendocrine differentiation of lung epithelium as an additional prototypic 'lineage-survival oncogene'
Hirotaka Osada and Takashi Takahashi
doi:10.1038/nrc1947-c1
Author Reply: Inclusion of the ASH1 gene that governs the neuroendocrine differentiation of lung epithelium as an additional prototypic 'lineage-survival oncogene'
Levi A. Garraway and William R. Sellers
doi:10.1038/nrc1947-c2
Correspondence
Correspondence: Antigen expression profile in circulating endothelial progenitor cells
Jean-Pierre Gagner and Peter Shamamian
doi:10.1038/nrc1971-c1
Author Reply: The authors reply
Francesco Bertolini, Yuval Shaked, Patrizia Mancuso and Robert S. Kerbel
doi:10.1038/nrc1971-c2