Table of contents
From the editors
p573 | doi:10.1038/nrc1968
Research Highlights
Leukaemia stem cells: Self-renewal-associated signature
p575 | doi:10.1038/nrc1964
Immunotherapy: A steady target
p576 | doi:10.1038/nrc1959
Leukaemia: Wandering downstream
p576 | doi:10.1038/nrc1965
Oncogenes: Keeping it in the family
p577 | doi:10.1038/nrc1957
Melanoma: Compare and contrast
p578 | doi:10.1038/nrc1963
Drug resistance: A taxing problem
p578 | doi:10.1038/nrc1966
In the news
Fruit bears fruit
p578 | doi:10.1038/nrc1967
Genetics: Flipping the switch
p579 | doi:10.1038/nrc1961
Microenvironment: Down to a T
p580 | doi:10.1038/nrc1956
Oncogenomics: Cross-species comparisons
p580 | doi:10.1038/nrc1962
In brief
Autophagy | Breast Cancer | Tumour Immunology | Tumour Classification
p580 | doi:10.1038/nrc1969
Tumour metabolism: Energy exchange
p581 | doi:10.1038/nrc1955
Reviews
Article series: Tumour Microenvironment
Drug penetration in solid tumours
Andrew I. Minchinton & Ian F. Tannock
p583 | doi:10.1038/nrc1893
Drug distribution within solid tumours is an often-neglected area of research in chemotherapeutic resistance. This Review summarizes the evidence that many chemotherapeutic drugs do not completely penetrate tumours, and suggests strategies to circumvent this problem.
Lineage dependency and lineage-survival oncogenes in human cancer
Levi A. Garraway & William R. Sellers
p593 | doi:10.1038/nrc1947
Microarray analyses have enabled tumours to be grouped on the basis of their genomic alterations rather than their tissue of origin. But does the identification of lineage-survival genes implicate lineage dependency (or lineage addiction) as a mechanism that is also affected by tumour genetic alterations?
The evolution of the population-based cancer registry
Donald M. Parkin
p603 | doi:10.1038/nrc1948
The role of cancer registries has expanded from the description of incidence trends to calculating survival and individual care management. Now, 21% of the world's population is covered by registries, and this review surveys the global situation.
Article series: Tumour Microenvironment
Targeting the mechanisms of tumoral immune tolerance with small-molecule inhibitors
Alexander J. Muller & Peggy A. Scherle
p613 | doi:10.1038/nrc1929
Recent advances in the understanding of tumour–host interactions have revealed some key effectors of tumoral immune escape that limit the successful use of treatments that rely on boosting immune function. Can some of these effectors be targeted by small-molecule inhibitors?
Predicting benefit from anti-angiogenic agents in malignancy
Adrian M. Jubb, Adam J. Oates, Scott Holden & Hartmut Koeppen
p626 | doi:10.1038/nrc1946
Biomarkers used in determining the response to cytotoxic agents are not optimal for predicting benefit from anti-angiogenic drugs. Which anti-angiogenic biomarkers might prove useful for identifying initial drug choice, appropriate dosing, early clinical benefit, emerging resistance and second-line treatments?
Perspectives
Opinion
Invasive growth: a MET-driven genetic programme for cancer and stem cells
Carla Boccaccio & Paolo M. Comoglio
p637 | doi:10.1038/nrc1912
Recent findings have indicated that the tyrosine-kinase receptor MET is a sensor of adverse microenvironmental conditions (such as hypoxia), and can drive cell invasion and metastasis through the transcriptional activation of a set of genes that control blood coagulation.
Science and society
A new model for cancer research in France
David Khayat & David Kerr
p645 | doi:10.1038/nrc1927
The new French National Cancer Institute (INCa) has brought cancer care, research and policy in France together for the first time. Three years after its conception, and one year after its inauguration, this article charts its aims and structure.
Correspondence
Correspondence: Association between biomarkers of environmental exposure and increased risk of breast cancer
Maryann Donovan, Tiffany D. Miles, Jean J. Latimer, Steven Grant, Evelyn Talbott, Annie J. Sasco & Devra L. Davis
| doi:10.1038/nrc1755-c1
Author Reply: Association between biomarkers of environmental exposure and increased risk of breast cancer
Deborah M. Winn
| doi:10.1038/nrc1755-c2
