Nature Reviews Cancer 6, 425-436 (June 2006) | doi:10.1038/nrc1889

Brain tumour stem cells

Angelo L. Vescovi1, Rossella Galli2 & Brent A. Reynolds3  About the authors


The dogma that the genesis of new cells is a negligible event in the adult mammalian brain has long influenced our perception and understanding of the origin and development of CNS tumours. The discovery that new neurons and glia are produced throughout life from neural stem cells provides new possibilities for the candidate cells of origin of CNS neoplasias. The emerging hypothesis is that alterations in the cellular and genetic mechanisms that control adult neurogenesis might contribute to brain tumorigenesis, thereby allowing the identification of new therapeutic strategies.

Author affiliations

  1. Department of Biotechnology and Biosciences, University of Milan Bicocca, Milan 20126, Italy.
  2. Stem Cell Research Institute, DIBIT, San Raffaele Scientific Institute, Via Olgettina 58, Milan 20132, Italy.
  3. University of Queensland, Brisbane 4072, Australia.

Correspondence to: Angelo L. Vescovi1 Email:


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