Review
Nature Reviews Cancer 6, 360-368 (May 2006) | doi:10.1038/nrc1879
Molecular mechanisms of oestrogen and SERMs in endometrial carcinogenesis
Yongfeng Shang1 About the author
Abstract
Endometrial cancer is the most common gynaecological cancer, and is associated with endometrial hyperplasia, unopposed oestrogen exposure and adjuvant therapy for breast cancer using selective oestrogen-receptor modulators (SERMs), particularly tamoxifen. Oestrogen and SERMs are thought to be involved in endometrial carcinogenesis through their effects on transcriptional regulation. Ultimately, oestrogen and SERMs affect the transduction of cellular signalling pathways that govern cell growth and proliferation, through downstream effectors such as PAX2 (paired box 2).
- View At a Glance
Author affiliations
-
Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100083, China.
Email: Jason@bjmu.edu.cn
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Raloxifene: Magic bullet for heart and bone?Nature Medicine News and Views (01 Feb 1998)
Breast cancer biology blossoms in the clinicNature Medicine News and Views (01 Jul 1998)
See all 3 matches for News And ViewsRESEARCH
Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesisNature Article (15 Dec 2005)
Clinicopathological and molecular analysis of endometrial carcinoma associated with tamoxifenModern Pathology Original Article
See all 29 matches for Research