Figures and Tables
From the following article:
Protein-tyrosine phosphatases and cancer
Arne Östman, Carina Hellberg & Frank D. Böhmer
Nature Reviews Cancer 6, 307-320 (April 2006)
doi:10.1038/nrc1837
Figure 1
Schematic representation of some of the protein-tyrosine phosphatase subfamilies.
Figure 2
Schematic illustration of the dual aspects of protein-tyrosine phosphatases in controlling cell proliferation, cell–matrix and cell–cell adhesion.
Figure 3
Schematic illustration of different mechanisms for protein-tyrosine phosphatase inactivation in cancer.
Figure 4
Mechanism of SHP2-mediated signal transduction and the effect of SHP2 mutations in leukaemia.
Table 1
Protein-tyrosine phosphatases with tumour-suppressive activity
Table 2
SHP2 (PTPN11) variants in Noonan syndrome, and malignancies
Table 3
Protein-tyrosine phosphatases with a proven or potential oncogenic role
