Review
Nature Reviews Cancer 6, 270-280 (April 2006) | doi:10.1038/nrc1838
Modelling cancer in human skin tissue
Paul A. Khavari1 About the author
Abstract
The capacity to induce neoplasia in human tissue in the laboratory has recently provided a new platform for cancer research. Malignant conversion can be achieved in vivo by expressing genes of interest in human tissue that has been regenerated on immune-deficient mice. Induction of cancer in regenerated human skin recapitulates the three-dimensional architecture, tissue polarity, basement membrane structure, extracellular matrix, oncogene signalling and therapeutic target proteins found in intact human skin in vivo. Human-tissue cancer models therefore provide an opportunity to elucidate fundamental cancer mechanisms, to assess the oncogenic potency of mutations associated with specific human cancers and to develop new cancer therapies.
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Author affiliations
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Veterans Affairs, Palo Alto Healthcare System, Palo Alto, California 94304, and the Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA.
Email: khavari@CMGM.stanford.edu
Published online 16 March 2006
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