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Volume 6 Issue 3, March 2006

From The Editors

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Research Highlight

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In the News

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Research Highlight

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In Brief

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Research Highlight

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Trial Watch

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Review Article

  • Integrins contribute to squamous cell carcinoma as well as invasion and metastasis. Mutation or upregulation of integrins in tumour cells can inhibit differentiation and apoptosis, and integrins that are expressed by differentiated cells can alter the proliferation of neighbouring tumour stem cells.

    • Sam M. Janes
    • Fiona M. Watt
    Review Article
  • Despite the success in treating childhood leukaemia, its causes remain enigmatic. A plethora of candidate environmental exposures have been proposed but, as this review discusses, an abnormal immune response to common infection(s) has emerged as the most plausible aetiological mechanism.

    • Mel Greaves
    Review Article
  • Why should vaccines be particularly effective in cancer prevention? Guido Forni and colleagues discuss the rationale for, and the challenges involved in, developing such preventive vaccines.

    • Pier-Luigi Lollini
    • Federica Cavallo
    • Guido Forni
    Review Article
  • This review examines whether the ASPP family of p53-interacting proteins are a missing link in the regulation of p53-induced cell-cycle arrest and apoptosis.

    • Giuseppe Trigiante
    • Xin Lu
    Review Article
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Perspectives

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Opinion

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Corrigendum

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Correspondence

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