Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 6 Issue 1, January 2006

From The Editors

Top of page ⤴

Research Highlight

    • Kristine Novak
    Research Highlight
Top of page ⤴

Trial Watch

Top of page ⤴

Research Highlight

Top of page ⤴

In the News

Top of page ⤴

In Brief

Top of page ⤴

Review Article

  • Krüppel-like factors are transcriptional regulators that function both as tumour suppressors and oncogenes through their control of p21 expression. This might be an important nodal point of cell control for other factors that have opposing functions in cancer.

    • Benjamin D. Rowland
    • Daniel S. Peeper
    Review Article
  • This review examines how recent insights, gained from mouse models, have improved our understanding of the contradictory role of adaptive and innate leukocytes in cancer development.

    • Karin E. de Visser
    • Alexandra Eichten
    • Lisa M. Coussens
    Review Article
  • The transcription factors of the Pax gene family are important in growth regulation and, therefore, the prevention of malignant growth. This review examines their roles in embryogenesis and how these can be subverted to contribute to tumorigenesis.

    • Ewan J. D. Robson
    • Shu-Jie He
    • Michael R. Eccles
    Review Article
  • Predicting cancer occurrence is a difficult task. However, if predictions are accurate, they can be useful to health planners trying to optimize resources, and to assess the impact of planned interventions. How are predictions made and what are the challenges?

    • Freddie Bray
    • Bjørn Møller
    Review Article
Top of page ⤴

Timeline

  • In the 25 years since Doll and Peto published their groundbreaking report on the causes of cancers and strategies for prevention, there have been many additional epidemiological studies of cancer incidence. What do we now know about opportunities for cancer prevention?

    • Graham A. Colditz
    • Thomas A. Sellers
    • Edward Trapido
    Timeline
Top of page ⤴

Science and Society

  • Accessible information about the presence and effect of specific mutations in cancer-causing genes is essential, but keeping track of these mutations is not simple. This article, using p53 as an example, highlights the difficulties involved in maintaining mutation databases.

    • Thierry Soussi
    • Chikashi Ishioka
    • Christophe Béroud
    Science and Society
Top of page ⤴

Correspondence

Top of page ⤴

Search

Quick links