Abstract

Neurofibromatosis type 1 (NF1) is a common genetic condition in which affected individuals develop benign and malignant nervous system tumours. Genetically engineered mouse (GEM) models of these NF1-associated nervous system tumours recapitulate several of the unique clinical aspects of the disease. Moreover, these Nf1 GEM models allow for a direct examination of the earliest stages of tumour evolution, including the contributions that Nf1^+/- cellular elements and cooperating genetic changes make to facilitate the transition from the pre-neoplastic to the neoplastic state and, in some cases, to promote malignant progression.

Author affiliations

1. Joshua B. Rubin is in the Departments of Pediatrics and Anatomy and Neurobiology, Washington University School of Medicine and St. Louis Children's Hospital, St. Louis Missouri 63110, USA.
2. David H. Gutmann is in the Department of Neurology, Washington University School of Medicine and St. Louis Children's Hospital, St. Louis Missouri 63110, USA.

Correspondence to: David H. Gutmann² Email: gutmannd@neuro.wustl.edu

MORE ARTICLES LIKE THIS

These links to content published by NPG are automatically generated.