Review
Nature Reviews Cancer 5, 516-525 (July 2005) | doi:10.1038/nrc1650
Repopulation of cancer cells during therapy: an important cause of treatment failure
John J. Kim1 & Ian F. Tannock2 About the authors
Abstract
Radiotherapy and chemotherapy are given in multiple doses, which are spaced out to allow the recovery of normal tissues between treatments. However, surviving cancer cells also proliferate during the intervals between treatments and this process of repopulation is an important cause of treatment failure. Strategies developed to overcome repopulation have improved clinical outcomes, and now new strategies to inhibit repopulation are emerging in parallel with advances in the understanding of underlying biological mechanisms.
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Author affiliations
- Department of Radiation Oncology, Princess Margaret Hospital and University of Toronto, 610 University Avenue, Toronto, ON M5G 2M9, Canada.
- Department of Medical Oncology, Princess Margaret Hospital and University of Toronto, 610 University Avenue, Toronto, ON M5G 2M9, Canada.
Correspondence to: Ian F. Tannock2 Email: ian.tannock@uhn.on.ca
Published online 20 June 2005
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