Review
Nature Reviews Cancer 5, 376-387 (May 2005) | doi:10.1038/nrc1607
The runx genes: gain or loss of function in cancer
Karen Blyth1, Ewan R. Cameron1 About the authors & James C. Neil1
Abstract
The RUNX genes have come to prominence recently because of their roles as essential regulators of cell fate in development and their paradoxical effects in cancer, in which they can function either as tumour-suppressor genes or dominant oncogenes according to context. How can this family of transcription factors have such an ambiguous role in cancer? How and where do these genes impinge on the pathways that regulate growth control and differentiation? And what is the evidence for a wider role for the RUNX genes in non-haematopoietic cancers?
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Author affiliations
- Molecular Oncology Laboratory, Institute of Comparative Medicine, University of Glasgow Veterinary School, Glasgow, G61 1QH, UK.
Correspondence to: James C. Neil1 Email: J.C.Neil@vet.gla.ac.uk
Published online 20 April 2005
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