Abstract

The cytotoxicity of chemotherapeutic agents is attributed to apoptosis. Acquired resistance to the effects of chemotherapy has emerged as a significant impediment to effective cancer therapy. One feature that cytotoxic treatments of cancer have in common is their activation of the transcription factor nuclear factor-B (NF-B), which regulates cell survival. NF-B activation suppresses the apoptotic potential of chemotherapeutic agents and contributes to resistance. What evidence is there that inhibitors of NF-B might promote apoptosis in cancer cells and can NF-B inhibitors be used to overcome resistance to chemotherapeutic agents?

Author affiliations

1. Tokyo Metropolitan Cancer and Infectious Disease Center, Komagome Hospital, 3-18-22, Honkomagome, Bunkyoku, Tokyo 113-8677, Japan.
   Email: chikashi-n@world.ocn.ne.jp
   Email: maktoi77@wa2.so-net.ne.jp

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