Abstract

The inactivation of programmed cell death, or apoptosis, is central to the development of cancer. This disabling of apoptotic responses might be a major contributor both to treatment resistance and to the observation that, in many tumours, apoptosis is not the main mechanism for the death of cancer cells in response to common treatment regimens. Importantly, this suggests that other modes of cell death are involved in the response to therapy.

Author affiliations

1. J. Martin Brown and Laura D. Attardi are at the Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford, California 94305, USA.

Correspondence to: J. Martin Brown¹ Email: mbrown@stanford.edu

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