Figures and Tables

From the following article:

Promoting apoptosis as a strategy for cancer drug discovery

Stephen W. Fesik

Nature Reviews Cancer 5, 876-885 (November 2005)

doi:10.1038/nrc1736

Figure 1 - Promoting apoptosis as a strategy for cancer drug discovery

Figure 1

Simplified representation of the two main signalling pathways of programmed cell death.

Figure 2 - Promoting apoptosis as a strategy for cancer drug discovery

Figure 2

Three-dimensional structures of BCL-XL and a two-dimensional structure of a BCL2-family inhibitor.

Figure 3 - Promoting apoptosis as a strategy for cancer drug discovery

Figure 3

Anti-tumour activity of ABT-737 observed in vivo in a small cell lung carcinoma xenograft mouse model.

Figure 4 - Promoting apoptosis as a strategy for cancer drug discovery

Figure 4

Structures of SMAC mimetics.

Figure 5 - Promoting apoptosis as a strategy for cancer drug discovery

Figure 5

MDM2 inhibitors.

Table 1 - Promoting apoptosis as a strategy for cancer drug discovery

Table 1

Status of apoptosis-inducing agents