Review
Nature Reviews Cancer 5, 867-875 (November 2005) | doi:10.1038/nrc1735
Radiation and the microenvironment – tumorigenesis and therapy
Mary Helen Barcellos-Hoff1, Catherine Park2 & Eric G. Wright3 About the authors
Abstract
Radiation rapidly and persistently alters the soluble and insoluble components of the tissue microenvironment. This affects the cell phenotype, tissue composition and the physical interactions and signalling between cells. These alterations in the microenvironment can contribute to carcinogenesis and alter the tissue response to anticancer therapy. Examples of these responses and their implications are discussed with a view to therapeutic intervention.
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Author affiliations
- Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, California 94720, USA.
- Department of Radiation Oncology, University of California, San Francisco, San Francisco, California 94143, USA.
- Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD19SY, Scotland, UK.
Correspondence to: Mary Helen Barcellos-Hoff1 Email: mhbarcellos-hoff@lbl.gov
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