Review
Nature Reviews Cancer 5, 786-795 (October 2005) | doi:10.1038/nrc1713
The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis
Rosa A. Cardone1, Valeria Casavola1 & Stephan J. Reshkin1 About the authors
Abstract
Recent research has highlighted the fundamental role of the tumour's extracellular metabolic microenvironment in malignant invasion. This microenvironment is acidified primarily by the tumour-cell Na+/H+ exchanger NHE1 and the H+/lactate cotransporter, which are activated in cancer cells. NHE1 also regulates formation of invadopodia — cell structures that mediate tumour cell migration and invasion. How do these alterations of the metabolic microenvironment and cell invasiveness contribute to tumour formation and progression?
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Author affiliations
- Department of General and Environmental Physiology, University of Bari, Via Amendola 165/A, 70126 Bari, Italy.
Correspondence to: Stephan J. Reshkin1 Email: reshkin@biologia.uniba.it
Published online 20 September 2005
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