Review
Nature Reviews Cancer 4, 677-687 (September 2004) | doi:10.1038/nrc1430
Nuclear structure in cancer cells
Daniele Zink1, Andrew H. Fischer2 & Jeffrey A. Nickerson3 About the authors
Abstract
Nuclear architecture — the spatial arrangement of chromosomes and other nuclear components — provides a framework for organizing and regulating the diverse functional processes within the nucleus. There are characteristic differences in the nuclear architectures of cancer cells, compared with normal cells, and some anticancer treatments restore normal nuclear structure and function. Advances in understanding nuclear structure have revealed insights into the process of malignant transformation and provide a basis for the development of new diagnostic tools and therapeutics.
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Author affiliations
- University of Munich (LMU), Department of Biology II, Goethestr. 31, 80336 Munich, Germany.
- Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue, Worcester, Massachusetts 01655, USA.
- Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue, Worcester, Massachusetts 01655, USA.
Correspondence to: Daniele Zink1 Email: Dani.Zink@lrz.uni-muenchen.de
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