Perspectives
Nature Reviews Cancer 4, 481-487 (June 2004) | doi:10.1038/nrc1372
Opinion: Yeast as a model system for anticancer drug discovery
Julian A. Simon1 & Antonio Bedalov2 About the authors
Abstract
Yeast is widely used as a model organism for investigating many aspects of eukaryotic cell biology. It combines a high level of conservation between its cellular processes and those of mammalian cells with advantages such as simple growth requirements, rapid cell division, ease of genetic manipulation and a wealth of experimental tools for genome-wide analysis of biological functions. How can these advantages be put to use in anticancer drug discovery?
Author affiliations
- Julian A. Simon is at the Clinical Research and Human Biology Divisions, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
- Antonio Bedalov is at the Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Correspondence to: Julian A. Simon1 Email: jsimon@fhcrc.org
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Identification of IGFBP-6 as an effector of the tumor suppressor activity of SEMA3BOncogene Original Article
Persistent transactivation of EGFR and ErbB2/HER2 by protease-activated receptor-1 promotes breast carcinoma cell invasionOncogene Original Article
Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylaseThe EMBO Journal Article (16 Jun 2004)
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effectOncogene Original Article
See all 21 matches for Research