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Perspective

Nature Reviews Cancer 4, 401–411 (1 May 2004) | doi:10.1038/nrc1359

The promise of cancer vaccines

Eli Gilboa

From early excitement to total disillusionment and now gaining momentum again, cancer vaccination has been a real roller-coaster ride. Are the current expectations justified or will there be further disappointment? In this perspective article, I will discuss why the rationale of cancer vaccination does make sense after all and offer some thoughts and guidelines on how to get it right this time.