Review
Nature Reviews Cancer 4, 285-295 (April 2004) | doi:10.1038/nrc1320
Molecular targets in pituitary tumours
Anthony P. Heaney1 & Shlomo Melmed1 About the authors
Abstract
Pituitary tumours are associated with unrestrained secretion and subsequent action of trophic hormones. One approach to therapy involves suppressing pituitary-hormone hypersecretion without compromising endogenous pituitary function. Identification of novel neuroendocrine-receptor targets has enabled the development of safe and effective receptor ligands that can be used to treat pituitary tumours and associated hormonal excess. Some of these agents, such as somatostatin analogues and a growth-hormone-receptor antagonist, will also have broader applications in treating other cancers and metabolic disorders.
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Author affiliations
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Cedars-Sinai Research Institute, 8700 Beverly Blvd, Geffen School of Medicine at UCLA, Los Angeles, California 90048, USA.
Email: heaneya@cshs.org
Email: melmed@cshs.org
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