Review
Nature Reviews Cancer 4, 850-860 (November 2004) | doi:10.1038/nrc1476
Association studies for finding cancer-susceptibility genetic variants
Paul D. P. Pharoah1, Alison M. Dunning1, Bruce A. J. Ponder1 & Douglas F. Easton2 About the authors
Abstract
Cancer is the result of complex interactions between inherited and environmental factors. Known genes account for a small proportion of the heritability of cancer, and it is likely that many genes with modest effects are yet to be found. Genetic-association studies have been widely used in the search for such genes, but success has been limited so far. Increased knowledge of the function of genes and the architecture of human genetic variation combined with new genotyping technologies herald a new era of gene mapping by association.
- View At a Glance
Author affiliations
- Cancer Research UK Human Cancer Genetics Group, Department of Oncology, Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK.
- Genetic Epidemiology Group, Department of Public Health and Primary Care, Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK.
Correspondence to: Bruce A. J. Ponder1 Email: bruce.ponder@srl.cam.ac.uk
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Identification of IGFBP-6 as an effector of the tumor suppressor activity of SEMA3BOncogene Original Article
Temporal changes in allele frequency, genetic variation and inbreeding depression in small populations of the guppy, Poecilia reticulataHeredity Original Article
Interacting haplotypes at the NPAS3 locus alter risk of schizophrenia and bipolar disorderMolecular Psychiatry Original Article
A genome-wide association study identifies novel risk loci for type 2 diabetesNature Article (22 Feb 2007)
See all 45 matches for Research