Review
Nature Reviews Cancer 4, 36-44 (January 2004) | doi:10.1038/nrc1255
Paraneoplastic neurological degenerations: keys to tumour immunity
Matthew L. Albert1 & Robert B. Darnell1 About the authors
Abstract
Paraneoplastic neurological degenerations (PNDs) are neurological disorders that develop in patients with cancer. PNDs are triggered by an effective antitumour immune response against neuronal antigens that are expressed in cancer cells, which subsequently develops into autoimmune neurodegenerative disease. Studying patients with PND has offered the opportunity to gain unique insights into mechanisms of tumour immunity and has provided the potential to apply this knowledge to patients with cancer in general.
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Author affiliations
- Howard Hughes Medical Institute, The Rockefeller University, New York 10021, USA.
Correspondence to: Robert B. Darnell1 Email: darnelr@rockefeller.edu
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