Review
Nature Reviews Cancer 3, 601-614 (August 2003) | doi:10.1038/nrc1144
Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms
Sergio A. Lamprecht1 & Martin Lipkin1 About the authors
Abstract
Recent findings have indicated that dietary calcium, vitamin D and folate can modulate and inhibit colon carcinogenesis. Supporting evidence has been obtained from a wide variety of preclinical experimental studies, epidemiological findings and a few human clinical trials. Important molecular events and cellular actions of these micronutrients that contribute to their tumour-modulating effects are discussed. They include a complex series of signalling events that affect the structural and functional organization of colon cells.
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Author affiliations
- Strang Cancer Prevention Center and Strang Cancer Research Laboratory at The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA.
Correspondence to: Sergio A. Lamprecht1 Email: lampres@mail.rockefeller.edu