Review
Nature Reviews Cancer 3, 931-943 (December 2003) | doi:10.1038/nrc1230
The 14-3-3 cancer connection
Heiko Hermeking1 About the author
Abstract
14-3-3 proteins regulate many cellular processes that are important in cancer biology, such as apoptosis and cell-cycle checkpoints. There are seven human 14-3-3 genes and one of these, 14-3-3
, has been directly implicated in the aetiology of human cancer. Loss of 14-3-3 expression sensitizes cancer cells to conventional anticancer agents, so its inhibition could be exploited for therapeutic purposes. Interference with 14-3-3 function as a therapeutic approach is being evaluated at present and, in the case of UCN-01, is under clinical investigation.
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Author affiliations
- Molecular Oncology, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18a, D-82152 Martinsried, Germany. Email: herme@biochem.mpg.de
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