Review
Nature Reviews Cancer 3, 859-868 (November 2003) | doi:10.1038/nrc1209
AP-1: a double-edged sword in tumorigenesis
Robert Eferl1 & Erwin F. Wagner1 About the authors
Abstract
The AP-1 transcription factor is a dimeric complex that contains members of the JUN, FOS, ATF and MAF protein families. AP-1 proteins are primarily considered to be oncogenic, but recent studies have challenged this view — some AP-1 proteins, such as JUNB and c-FOS, have been shown to have tumour-suppressor activity. Here, we focus on the JUN and FOS proteins and aim to offer a new perspective on the molecular mechanisms that regulate the oncogenic and anti-oncogenic effects of AP-1 in tumour development.
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Author affiliations
- Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A-1030 Vienna, Austria.
Correspondence to: Robert Eferl1 Email: eferl@imp.univie.ac.at
Correspondence to: Erwin F. Wagner1 Email: wagner@imp.univie.ac.at
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