Review
Nature Reviews Cancer 3, 807-820 (November 2003) | doi:10.1038/nrc1208
Cytostatic and apoptotic actions of TGF-
in homeostasis and cancer
Peter M. Siegel1 & Joan Massagué1 About the authors
Abstract
The cytostatic and apoptotic functions of transforming growth factor-
(TGF-) help restrain the growth of mammalian tissues; loss of these effects leads to hyperproliferative disorders and is common in cancer. However, tumour cells that are relieved from TGF- growth constraints might then overproduce this cytokine to create a local immunosuppressive environment that fosters tumour growth and exacerbates the invasive and metastatic behaviour of the tumour cells themselves. For these reasons, there is a growing interest in understanding and therapeutically targeting TGF--mediated processes in cancer progression.
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Author affiliations
- Cancer Biology and Genetics Program, Howard Hughes Medical Institute, Memorial Sloan–Kettering Cancer Center, New York, NY 10021, USA.
Correspondence to: Joan Massagué1 Email: j-massague@ski.mskcc.org
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