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Review
Nature Reviews Cancer 3, 756–767 (1 October 2003) | doi:10.1038/nrc1186
The role of Notch in tumorigenesis: oncogene or tumour suppressor?
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Abstract
Notch signalling participates in the development of multicellular organisms by maintaining the self-renewal potential of some tissues and inducing the differentiation of others. Involvement of Notch in cancer was first highlighted in human T-cell leukaemia, fuelling the notion that aberrant Notch signalling promotes tumorigenesis. However, there is mounting evidence that Notch signalling is not exclusively oncogenic. It can instead function as a tumour suppressor.
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