Review
Nature Reviews Cancer 3, 35-45 (January 2003) | doi:10.1038/nrc971
Targeting tumours with genetically enhanced T lymphocytes
Michel Sadelain1, Isabelle Rivière1 & Renier Brentjens1 About the authors
Abstract
The genetic modification of T lymphocytes is an important approach to investigating normal T-cell biology and to increasing antitumour immunity. A number of genetic strategies aim to increase the recognition of tumour antigens, enhance antitumour activities and prevent T-cell malfunction. T cells can also be engineered to increase safety, as well as to express markers that can be tracked by non-invasive imaging technologies. Genetically modified T cells are therefore proving to be of great value for basic immunology and experimental immunotherapy.
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Author affiliations
- Department of Medicine and Immunology Program, Memorial Sloan–Kettering Cancer Center, New York, New York 10021, USA.
Correspondence to: Michel Sadelain1 Email: m-sadelain@ski.mskcc.org
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