Review

Nature Reviews Cancer 2, 563-572 (August 2002) | doi:10.1038/nrc865

Focus on: Metastasis

Metastasis: Dissemination and growth of cancer cells in metastatic sites

Ann F. Chambers1,2,3, Alan C. Groom3 & Ian C. MacDonald2,3  About the authors

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Metastases, rather than primary tumours, are responsible for most cancer deaths. To prevent these deaths, improved ways to treat metastatic disease are needed. Blood flow and other mechanical factors influence the delivery of cancer cells to specific organs, whereas molecular interactions between the cancer cells and the new organ influence the probability that the cells will grow there. Inhibition of the growth of metastases in secondary sites offers a promising approach for cancer therapy.

Author affiliations

  1. London Regional Cancer Centre, London, Ontario N6A 4L6, Canada.
  2. Department of Oncology, University of Western Ontario, London, Ontario N6A 4L6, Canada.
  3. Department of Medical Biophysics, University of Western Ontario, London, Ontario N6A 5C1, Canada.

Correspondence to: Ann F. Chambers1,2,3 Email: ann.chambers@lrcc.on.ca

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