Review
Nature Reviews Cancer 2, 502-513 (July 2002) | doi:10.1038/nrc840
Core-binding factors in haematopoiesis and leukaemia
Nancy A. Speck1 & D. Gary Gilliland2 About the authors
Abstract
Core-binding factors (CBFs) are a class of haematopoietic transcription factors that are crucial for the regulation of haematopoietic ontogeny, and are frequent targets of mutation and gene rearrangement in human leukaemia. So, what are the functions of CBFs during development, and what are the functional consequences of CBF mutations in leukaemia? Synergy between these convergent lines of enquiry has furthered our understanding of both normal and malignant haematopoiesis.
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Author affiliations
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Department of Biochemisty, Dartmouth Medical School, Hanover, New Hampshire 03755, USA.
Email: Nancy.A.Speck@Dartmouth.edu -
Howard Hughes Medical Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Email: gilliland@calvin.bwh.harvard.edu
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