Review

Nature Reviews Cancer 2, 431-441 (June 2002) | doi:10.1038/nrc823

Focus on: Stem Cells

Gene therapy to protect haematopoietic cells from cytotoxic cancer drugs

Brian P. Sorrentino1  About the author

Top

One of the most important complications of cancer chemotherapy is the toxic effect that the drugs have on normal tissues — particularly the bone marrow. Several gene-therapy vectors have been developed with the aim of expressing drug-resistance genes specifically in bone-marrow stem cells, so protecting them from chemotherapeutics. The feasibility of this approach has been established in animal model systems, and recent advances in the design of gene-therapy vectors offer promise for future clinical applications.

Top

Author affiliations

  1. Department of Hematology/Oncology, Division of Experimental Hematology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
    Email: brian.sorrentino@stjude.org
Top
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated

NEWS AND VIEWS
VEGF receptor 1 stimulates stem-cell recruitment and new hope for angiogenesis therapies
Nature Medicine News and Views (01 Aug 2002)

RESEARCH
Increased resistance to nitrogen mustards and antifolates following in vitro selection of murine fibroblasts and primary hematopoietic cells transduced with a bicistronic retroviral vector expressing the rat glutathione S-transferase A3 and a mutant dihydrofolate reductase
Cancer Gene Therapy Original Article (01 Aug 2003)
In vivo selection of retrovirally transduced hematopoietic stem cells
Nature Medicine Article (01 Oct 1998)

Extra navigation

Subscribe

Subscribe to Nature Reviews Cancer

Search PubMed for

naturejobs

More science jobs
Post a job for free

Advertisement