Review
Nature Reviews Cancer 2, 442-454 (June 2002) | doi:10.1038/nrc822
Epithelial–mesenchymal transitions in tumour progression
Jean Paul Thiery1 About the author
Abstract
Without epithelial–mesenchymal transitions, in which polarized epithelial cells are converted into motile cells, multicellular organisms would be incapable of getting past the blastula stage of embryonic development. However, this important developmental programme has a more sinister role in tumour progression. Epithelial–mesenchymal transition provides a new basis for understanding the progression of carcinoma towards dedifferentiated and more malignant states.
- View At a Glance
Author affiliations
-
Centre National Recherche Scientifique (CNRS) Unité Mixte Recherche (UMR), 144 Institut Curie, 26 rue d'Ulm, 75248 Paris cedex 05, France.
Email: jpthiery@curie.fr
|
MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated RESEARCH |
/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition
