Review

Nature Reviews Cancer 2, 342-350 (May 2002) | doi:10.1038/nrc798

Papillomaviruses and cancer: from basic studies to clinical application

Harald zur Hausen1  About the author

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Links between human papillomaviruses (HPVs) and cervical cancer were first suspected almost 30 years ago. DNA of specific HPV types has since been found in almost all cervical cancer biopsies. HPV oncogenes that are expressed in these cells are involved in their transformation and immortalization, and are required for the progression towards malignancy. Epidemiological studies have underlined that HPVs are the main aetiological factor for cervical cancer. But how has this knowledge been translated into the clinic to allow the prevention, screening and treatment of cervical cancer?

Author affiliations

  1. Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
    Email: zurhausen@dkfz-heidelberg.de
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REFERENCE
Papillomaviruses
Nature Encyclopaedia of Life Sciences

NEWS AND VIEWS
Cervical cancer: Papillomavirus and p53
Nature News and Views (21 May 1998)

RESEARCH
Variants of the long control region and the E6 oncogene in European human papillomavirus type 16 isolates: implications for cervical disease
British Journal of Cancer Original Article (21 Jan 2002)
Characterization of viral-cellular fusion transcripts in a large series of HPV16 and 18 positive anogenital lesions
Oncogene Original Article (17 Jan 2002)
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