Review
Nature Reviews Cancer 2, 301-310 (April 2002) | doi:10.1038/nrc780
NF-
B in cancer: from innocent bystander to major culprit
Michael Karin1, Yixue Cao1, Florian R. Greten1 & Zhi-Wei Li1 About the authors
Abstract
Nuclear factor of 
B (NF-B) is a sequence-specific transcription factor that is known to be involved in the inflammatory and innate immune responses. Although the importance of NF-B in immunity is undisputed, recent evidence indicates that NF-B and the signalling pathways that are involved in its activation are also important for tumour development. NF-B should therefore receive as much attention from cancer researchers as it has already from immunologists.
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Author affiliations
- Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
Correspondence to: Michael Karin1 Email: karinoffice@ucsd.edu
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