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SV40 and human tumours: myth, association or causality?

Nature Reviews Cancer volume 2, pages 957–964 (2002)Cite this article

Abstract

An increasing number of scientific reports have described evidence for a polyomavirus, simian virus 40, in a highly select group of human tumours. How did a simian virus infect humans and is the virus a passenger in tumours or is it important in their pathogenesis?

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Acknowledgements

Adi Gazdar's work was supported by a grant from the Early Detection Research Network and the National Cancer Institute. Michele Carbone's work was supproted by grants from the National Cancer Institute and American Cancer Society.

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Authors and Affiliations

  1. Hamon Center for Therapeutic Oncology Research and Department of Pathology, University of Texas Southwestern Medical Centre, Dallas, 75390, Texas, USA

    Adi F. Gazdar

  2. Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, 77030, Texas, USA

    Janet S. Butel

  3. Cardinal Bernardin Cancer Centre and Department of Pathology, Loyola University Chicago, Maywood, 60153, Illinois, USA

    Michele Carbone

Authors
  1. Adi F. Gazdar
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  2. Janet S. Butel
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  3. Michele Carbone
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Corresponding author

Correspondence to Adi F. Gazdar.

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DATABASES

GenBank

SV40

LocusLink

MET

NOTCH-1

p53

PP2A

RASSF1A

RB

FURTHER INFORMATION

AIDS

Encyclopedia of Life Sciences

hepatitis B

hepatitis C

HIV-1

papillomavirus

National Academies

The International Agency for Research in Cancer

World Health Organization

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Gazdar, A., Butel, J. & Carbone, M. SV40 and human tumours: myth, association or causality?. Nat Rev Cancer 2, 957–964 (2002). https://doi.org/10.1038/nrc947

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