Perspective
Nature Reviews Cancer 2, 795-803 (October 2002) | doi:10.1038/nrc909
Timeline: VEGF and the quest for tumour angiogenesis factors
Napoleone Ferrara1 About the author
Abstract
The ability of tumours to induce new blood-vessel formation has been a major focus of cancer research over the past few decades, and vascular endothelial growth factor (VEGF) is now known to be central to this process. The quest for VEGF and other factors that promote tumour angiogenesis was initiated many decades ago, and a long and complicated path has led to the development of inhibitors of these molecules as anticancer agents. How did this field begin, and how have we arrived at our present understanding of the role of VEGF in tumour progression.
Author affiliations
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Napoleone Ferrara is at the Department of Molecular Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA.
Email: nf@gene.com
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