Review
Nature Reviews Cancer 2, 764-776 (October 2002) | doi:10.1038/nrc904
Corrected online: 2002 October 08
c-MYC: more than just a matter of life and death
Stella Pelengaris1, Mike Khan1 About the authors & Gerard Evan2
Abstract
Deregulated expression of c-MYC occurs in a broad range of human cancers and is often associated with poor prognosis, indicating a key role for this oncogene in tumour progression. However, as established human tumours often bear multiple genetic lesions, it is difficult to determine whether c-MYC is instrumental in the initiation/progression of the tumour, or indeed whether inactivating c-MYC would lead to tumour regression. Regulatable transgenic mouse models of oncogenesis have shed light on these issues and provide hope for effective cancer therapies.
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Author affiliations
- Molecular Medicine Research Centre, University of Warwick, Coventry CV4 7AL, UK.
- University of California San Francisco, Box 0875, San Francisco, California 94143?0875, USA.
Correspondence to: Stella Pelengaris1 Email: SPelengaris@bio.warwick.ac.uk
* Text accompanying certain citations was incorrectly placed (refs. 53, 55, 60, 84, 87, 92, 104, 119, 127, 135 in pdf and print) The text was moved to Refs. 54,56, 61, 87, 90, 97, 107, 126, 108, 111 respectively.
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