Review
Nature Reviews Cancer 2, 28-37 (January 2002) | doi:10.1038/nrc703
Helicobacter pylori and gastrointestinal tract adenocarcinomas
Richard M. Peek, Jr1 & Martin J. Blaser2 About the authors
Abstract
Although gastric adenocarcinoma is associated with the presence of Helicobacter pylori in the stomach, only a small fraction of colonized individuals develop this common malignancy. H. pylori strain and host genotypes probably influence the risk of carcinogenesis by differentially affecting host inflammatory responses and epithelial-cell physiology. Understanding the host–microbial interactions that lead to neoplasia will improve cancer-targeted therapeutics and diagnostics, and provide mechanistic insights into other malignancies that arise within the context of microbially initiated inflammatory states.
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Author affiliations
- Division of Gastroenterology, Vanderbilt University School of Medicine, C-2104 Medical Center North, Nashville, Tennessee 37232-2279, USA.
- Departments of Medicine and Microbiology, New York University School of Medicine and New York Harbor Veterans Affairs Medical Center, New York, New York 10016, USA.
Correspondence to: Richard M. Peek, Jr1 Email: richard.peek@mcmail.vanderbilt.edu
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