Current Issue

Research Highlights

Immunotherapy: T cells get a ride | PDF (87 KB)

p333 | doi:10.1038/nrc.2017.39

Tumorigenesis: Cancer as a symptom of evolution? | PDF (518 KB)

p373 | doi:10.1038/nrc.2017.33

A paper in Science by Tomasetti, Li and Vogelstein develops their 'bad luck' model further and explores how different sources of DNA mutation influence different cancer types.

Metastasis: The plastic state | PDF (157 KB)

p373 | doi:10.1038/nrc.2017.34

ZEB1-mediated epithelial-mesenchymal transition (EMT) and cellular plasticity promotes metastasis in pancreatic cancer.

In brief

Genetics: Gender-specific factors in cancer susceptibility | PDF (89 KB)

p372 | doi:10.1038/nrc.2017.37

Immunotherapy: Programming T cells in situ | PDF (89 KB)

p372 | doi:10.1038/nrc.2017.38



The ETS family of oncogenic transcription factors in solid tumours

Gina M. Sizemore, Jason R. Pitarresi, Subhasree Balakrishnan & Michael C. Ostrowski

p337 | doi:10.1038/nrc.2017.20

Initially identified more than 30 years ago, the ETS family of transcription factors has been found to take part in all steps of tumorigenesis. This Review discusses the different mechanisms of ETS activation and the oncogenic implications of this activation, as well as how to target ETS factors in cancer treatment.

Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy

Silvia von Karstedt, Antonella Montinaro & Henning Walczak

p352 | doi:10.1038/nrc.2017.28

Clinical trials testing activators of tumour necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) signalling in cancer have not met expectations. This Review discusses new insights that might explain clinical failure, but also provide the basis for harnessing TRAIL-Rs for cancer therapy.

The calcium–cancer signalling nexus

Gregory R. Monteith, Natalia Prevarskaya & Sarah J. Roberts-Thomson

p367 | doi:10.1038/nrc.2017.18

Changes in the calcium signal enable cells to achieve specific outcomes. In this Review, Monteith et al. describe how the remodelling of the expression and activity of calcium channels and pumps in cancer cells can influence tumour progression.

RNA editing-dependent epitranscriptome diversity in cancer stem cells

Qingfei Jiang, Leslie A. Crews, Frida Holm & Catriona H. M. Jamieson

p381 | doi:10.1038/nrc.2017.23

This Review discusses the roles of deregulated RNA processing, including RNA methylation, RNA editing, RNA splicing and RNA binding protein activity, in cancer stem cells and highlights the potential of these events as biomarkers and therapeutic targets.