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Two papers show that specific diets or pharmacological agents that mimic fasting inhibit tumour growth in combination with chemotherapy through effects on the immune system.
In response to tumour-derived signals, fibroblastic reticular cells within tumour-draining lymph nodes acquire a unique gene signature which in turn disrupts the composition and localization of lymph node immune cell populations.
Acquired resistance to programmed cell death 1 blockade in patients with melanoma is associated with defects in the pathways involved in interferon-receptor signalling.
This Review brings many aspects of pancreatic ductal adenocarcinoma research into a single concept rooted in Darwinian evolution, with the goal of identifying novel insights and opportunities for future study.
This Review assesses what we have learnt about adoptive cell transfer of engineered T cells for the treatment of patients with B cell malignancies and discusses how this therapy can be improved and applied to other malignancies, including solid tumours.
Cancer is associated with fibroblasts at all stages of disease progression. This Review discusses the pleiotropic actions of cancer-associated fibroblasts (CAFs) on tumour cells and postulates that they are likely to be a heterogeneous and plastic population of cells in the tumour microenvironment.
This Review summarizes our current understanding of the functions of established and emerging hereditary breast and ovarian cancer genes in genome maintenance pathways. The authors discuss how classifying variants as pathogenic by structural and functional analysis will aid clinical management.
