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Papaemmanuilet al. have described new mutations that drive acute myeloid leukaemia and classify the disease in distinct subgroups associated with different diagnostic features and clinical outcomes
The identification of multiple independent cancer lineages in multiple bivalve species makes transmissible cancers a common event, not exclusively restricted to the species of origin.
Whereas activation of p21 by p53 causes G1 cell cycle arrest, p53-independent expression of p21 can cause deregulation of DNA replication and genomic instability.
Jianget al. show that inhibition of focal adhesion kinase (FAK) reduces immunosuppression and fibrosis in pancreatic ductal adenocarcinoma (PDAC) and can improve the efficacy of both chemotherapy and immunotherapy in PDAC mouse models.
The discovery of cancer mutations that affect enhancer elements has generated interest in mapping and targeting cancer-specific enhancers, as discussed in this Review.
This Review discusses the increased understanding of the biology of T cell acute lymphoblastic leukaemia (T-ALL) and how this has translated into new prognostic biomarkers, improved animal models and the emergence of targeted therapies to combat this disease.
Given the important roles of telomerase in cancer, it is an attractive therapeutic target. This Review discusses our current knowledge of telomerase activities in cancer and strategies for therapeutic exploitation.
This Review summarizes the successes and challenges of using different types of molecules as biomarkers, using lung cancer as a key illustrative example. This article also discusses the future of precision medicine and national-level efforts to better treat patients with cancer.
Apoptotic cell death undoubtedly has beneficial roles in cancer, but paradoxically, apoptosis can also cause unwanted effects that could promote cancer. This Opinion article highlights some of the ways in which apoptosis can exert oncogenic functions.