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Volume 16 Issue 10, October 2016

'The building blocks of cancer' by Lara Crow, inspired by this Focus issue.

Foreword

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Research Highlight

  • Acidosis reprograms the metabolism of cancer cells toward fatty acid oxidation by downregulating acetyl-CoA carboxylase ACC2 through histone deacetylation

    • M. Teresa Villanueva
    Research Highlight
  • Sousaet al. demonstrate a reciprocal metabolic cross-talk between pancreatic stellate cells (PSCs) and pancreatic tumour cells whereby secreted autophagic alanine from PSCs is taken up by tumour cells and used as an alternative carbon source to support tumour growth.

    • Anna Dart
    Research Highlight
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In Brief

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Research Highlight

  • Chaeet al. show that mitochondrially-localized AKT phosphorylates pyruvate dehydrogenase kinase 1 (PDK1) to promote tumour cell growth and survival in hypoxic conditions.

    • Sarah Seton-Rogers
    Research Highlight
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Review Article

  • Serine supports many biosynthetic pathways, including the one-carbon cycle. This Review discusses how cancer cells acquire and use serine, and explores novel therapeutic approaches to limit serine metabolism.

    • Ming Yang
    • Karen H. Vousden
    Review Article
  • The availability of oxygen and nutrients changes during tumour evolution, which can have an effect on gene expression and diverse metabolic reactions as cells try to adapt to the new environment. In this Review the authors summarize how these metabolic adaptations are integrated in hypoxic tumour cells and their role in disease progression.

    • Michael S. Nakazawa
    • Brian Keith
    • M. Celeste Simon
    Review Article
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