Sae-Won Han, Hwang-Phill Kim and colleagues investigated RNA editing in colorectal cancer (CRC) samples. Whole genome and transcriptome sequence data showed an increase in adenosine-to-inosine editing in RAS homologue family member Q (RHOQ), which resulted in a substitution of asparagine with serine at residue 136 (RHOQN136S). The RHOQN136S protein had increased activity compared with wild-type RHOQ, and this was associated with a reorganization of the actin cytoskeleton and increased invasive potential of cells in vitro: invasive growth in vitro was further increased in the presence of mutant KRAS. In patients with CRC, edited RHOQ transcripts and mutant KRAS were associated with disease recurrence.
References
Han, S.-W. et al. RNA editing in RHOQ promotes invasion potential in colorectal cancer. J. Exp. Med. http://dx.doi.org/10.1084/jem.20132209 (2014)
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McCarthy, N. Editing an invasion. Nat Rev Cancer 14, 297 (2014). https://doi.org/10.1038/nrc3735
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DOI: https://doi.org/10.1038/nrc3735