Tumours that have lost BRCA2 are characterized by alterations in whole chromosome numbers and by chromosomal structural defects. This paper highlights a function of BRCA2 in cytokinesis. BRCA2 localizes to the midbody through its interaction with filamin A, and recruits ALIX and TSG101, which are endosomal sorting complex required for transport (ESCRT)-associated proteins. This enables the formation of CEP55–ALIX and CEP55–TSG101 complexes involved in abscission. Cancer-relevant BRCA2 mutations prevent the formation of these complexes and result in aberrant cytokinesis, and so might explain aneuploidy in BRCA2-mutant tumours.
ORIGINAL RESEARCH PAPER
Mondal, G. et al. BRCA2 localization to the midbody by filamin A regulates CEP55 signaling and completion of cytokinesis. Dev. Cell 5 Jul 2012 (doi:10.1016/j.devcel.2012.05.008)
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McCarthy, N. Divide and conquer. Nat Rev Cancer 12, 511 (2012). https://doi.org/10.1038/nrc3336
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DOI: https://doi.org/10.1038/nrc3336
