Nature Reviews Cancer 12, 445-446 (July 2012) | doi:10.1038/nrc3287

Unifying metastasis — integrating intravasation, circulation and end-organ colonization

Jacob Scott1,2, Peter Kuhn3 & Alexander R. A. Anderson1


Recent technological advances that have enabled the measurement of circulating tumour cells (CTCs) in patients have spurred interest in the circulatory phase of metastasis. Techniques that do not solely rely on a blood sample allow substantial biological interrogation beyond simply counting CTCs.

Author affiliations

  1. Integrated Mathematical Oncology, Moffitt Cancer Center, Tampa, Florida 33612, USA.
  2. Oxford University Centre for Mathematical Biology, Mathematical Institute, Oxford OX1 3LB, UK.
  3. Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

Correspondence to: Alexander R. A. Anderson1 Email:

Correspondence to: Jacob Scott1,2 Email:

Published online 24 May 2012