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Volume 12 Issue 5, May 2012

Research Highlight

  • Two recent papers published inNaturereport on genomic changes in cancer cell lines that indicate sensitivity to targeted drugs.

    • Chris Gunter
    Research Highlight

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  • A new study links HIF signalling to cyclin D1 expression through a novel enhancer function of a cancer susceptibility locus.

    • Darren J. Burgess
    Research Highlight
  • The transcription factor SIX1 can promote lymphangiogenesis and metastasis through regulating the expression of vascular endothelial growth factor C.

    • Nicola McCarthy
    Research Highlight
  • The extent of tumour heterogeneity has been explored in a paper recently published in theNew England Journal of Medicine.

    • Nicola McCarthy
    Research Highlight
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In the News

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Research Highlight

  • A paper inCellidentifies a subpopulation of intestinal stem cells that are characterized by the expression of LRIG1, which the authors show is a tumour suppressor.

    • Gemma K. Alderton
    Research Highlight
  • A clinical trial in mice with lung cancer indicates the likely efficacy of the MEK inhibitor selumetinib in a current ongoing human clinical trial.

    • Nicola McCarthy
    Research Highlight
  • The results of two trials suggest ways in which the treatment of advanced, relapsed or refractory Hodgkin's lymphoma might be improved.

    Research Highlight
  • Some of the pathways through which the transcription factor and potential tumour suppressor Cut regulates both differentiation and apoptosis inDrosophila melanogasterhave been identified.

    • Nicola McCarthy
    Research Highlight
  • Michael Ohh and colleagues delineate a pathway in which HIF increases the expression of caveolin 1, leading to increased ligand-independent mitogenic signalling by EGFR in cancer cells.

    • Sarah Seton-Rogers
    Research Highlight
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Review Article

  • Populations of tumour cells display remarkable phenotypic diversity as a result of both genetic and non-genetic influences. This Review discusses underlying causes of this intra-tumour phenotypic heterogeneity, and why this phenomenon may affect our ability to diagnose and effectively treat tumours.

    • Andriy Marusyk
    • Vanessa Almendro
    • Kornelia Polyak

    Collection:

    Review Article
  • This review discusses some of the new insights on the development of multiple myeloma that can be gained from considering the evolution of this disease from a Darwinian perspective.

    • Gareth J. Morgan
    • Brian A. Walker
    • Faith E. Davies
    Review Article
  • There are multiple subclasses of melanoma that are partly categorized on the basis of their oncogenic molecular drivers. As discussed in this Review, the understanding of the molecular features of melanoma has led to several exciting advances in the treatment of patients with melanoma.

    • Keith T. Flaherty
    • F. Stephen Hodi
    • David E. Fisher
    Review Article
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Innovation

  • Technological advances in optical coherence tomography (OCT) have enabled this imaging tool to be used to characterize various aspects of tumour biology in vivo. This Innovation article discusses the distinguishing features of OCT, its successful preclinical applications and its potential for clinical adoption.

    • Benjamin J. Vakoc
    • Dai Fukumura
    • Brett E. Bouma
    Innovation
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Essay

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Correspondence

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