Perspectives

Nature Reviews Cancer 11, 523-532 (July 2011) | doi:10.1038/nrc3081

OpinionDynamic modelling of oestrogen signalling and cell fate in breast cancer cells

John J. Tyson1, William T. Baumann2, Chun Chen3, Anael Verdugo1, Iman Tavassoly3, Yue Wang2, Louis M. Weiner4 & Robert Clarke4  About the authors

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Cancers of the breast and other tissues arise from aberrant decision-making by cells regarding their survival or death, proliferation or quiescence, damage repair or bypass. These decisions are made by molecular signalling networks that process information from outside and from within the breast cancer cell and initiate responses that determine the cell's survival and reproduction. Because the molecular logic of these circuits is difficult to comprehend by intuitive reasoning alone, we present some preliminary mathematical models of the basic decision circuits in breast cancer cells that may aid our understanding of their susceptibility or resistance to endocrine therapy.

Author affiliations

  1. John J. Tyson and Anael Verdugo are at the Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.
  2. William T. Baumann and Yue Wang are at the Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.
  3. Chun Chen and Iman Tavassoly are at the Graduate Program in Genetics, Bioinformatics and Computational Biology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.
  4. Louis M. Weiner and Robert Clarke are at the Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, District of Columbia 20057, USA.

Correspondence to: John J. Tyson1 Email: tyson@vt.edu

Published online 16 June 2011